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Heidelberg ( HY-dəl-burg, German: [ˈhaɪdl̩bɛʁk] (listen)) is a university town in the German state of Baden-Württemberg, situated on the river Neckar in south-west Germany. In the 2016 census, its population was 159,914, of which roughly a quarter consisted of students.Located about 78 km (48 mi) south of Frankfurt, Heidelberg is the fifth-largest city in Baden-Württemberg. Heidelberg is part of the densely populated Rhine-Neckar Metropolitan Region.
Heidelberg University, founded in 1386, is Germany's oldest and one of Europe's most reputable universities. Heidelberg is a scientific hub in Germany and home to several internationally renowned research facilities adjacent to its university, including the European Molecular Biology Laboratory and four Max Planck Institutes.
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Santiago (, US also ; Spanish: [sanˈtjaɣo]), also known as Santiago de Chile, is the capital and largest city of Chile as well as one of the largest cities in the Americas. It is the center of Chile's most densely populated region, the Santiago Metropolitan Region, whose total population is 7 million, of which more than 6 million live in the city's continuous urban area. The city is entirely in the country's central valley. Most of the city lies between 500–650 m (1,640–2,133 ft) above mean sea level.
Founded in 1541 by the Spanish conquistador Pedro de Valdivia, Santiago has been the capital city of Chile since colonial times. The city has a downtown core of 19th-century neoclassical architecture and winding side-streets, dotted by art deco, neo-gothic, and other styles.