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Heidelberg ( HY-dəl-burg, German: [ˈhaɪdl̩bɛʁk] (listen)) is a university town in the German state of Baden-Württemberg, situated on the river Neckar in south-west Germany. In the 2016 census, its population was 159,914, of which roughly a quarter consisted of students.Located about 78 km (48 mi) south of Frankfurt, Heidelberg is the fifth-largest city in Baden-Württemberg. Heidelberg is part of the densely populated Rhine-Neckar Metropolitan Region.
Heidelberg University, founded in 1386, is Germany's oldest and one of Europe's most reputable universities. Heidelberg is a scientific hub in Germany and home to several internationally renowned research facilities adjacent to its university, including the European Molecular Biology Laboratory and four Max Planck Institutes.
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Manchester () is a city and metropolitan borough in Greater Manchester, England. The city has a population of 547,627 (as of 2018) and lies within the United Kingdom's second-most populous urban area, with a population of 2.7 million and second-most populous metropolitan area, with a population of 3.3 million. It is fringed by the Cheshire Plain to the south, the Pennines to the north and east, and an arc of towns with which it forms a continuous conurbation. The local authority for the city is Manchester City Council.
The recorded history of Manchester began with the civilian settlement associated with the Roman fort of Mamucium or Mancunium, which was established in about AD 79 on a sandstone bluff near the confluence of the rivers Medlock and Irwell. Although historically and traditionally a part of Lancashire, areas of Cheshire south of the River Mersey were incorporated into Manchester in the 20th century. The first to be included, Wythenshawe, was added to the city in 1931. Throughout the Middle Ages Manchester remained a manorial township, but began to expand "at an astonishing rate" around the turn of the 19th century. Manchester's unplanned urbanisation was brought on by a boom in textile manufacture during the Industrial Revolution, and resulted in it becoming the world's first industrialised city.